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Common types and characteristics of direct compression auxiliary materials

Common types and characteristics of direct compression auxiliary materials

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  • Time of issue:2021-04-26 15:01
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Common types and characteristics of direct compression auxiliary materials

(Summary description)Microcrystalline cellulose This product is white or almost white powder, odorless, tasteless, insoluble in water, ethanol, acetone or toluene, has very good compressibility, and has certain fluidity and disintegration properties. It is a tablet Excellent fillers and effective dry binders have good hardness after being compressed into tablets, and do not affect disintegration. This variety has a relatively large capacity for drugs, and its dosage can range from 5% to 65%. But this species is hygroscopic. There are already products on the market in China.    Pregelatinized starch This product is white powder, odorless, tasteless, and has good fluidity. The national product has an angle of repose of 36.6 degrees, and has good compressibility; it has a lubricating effect and can reduce tablets

  • Categories:Company News
  • Author:
  • Origin:
  • Time of issue:2021-04-26 15:01
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Microcrystalline cellulose This product is white or almost white powder, odorless, tasteless, insoluble in water, ethanol, acetone or toluene, has very good compressibility, and has certain fluidity and disintegration properties. It is a tablet Excellent fillers and effective dry binders have good hardness after being compressed into tablets, and do not affect disintegration. This variety has a relatively large capacity for drugs, and its dosage can range from 5% to 65%. But this species is hygroscopic. There are already products on the market in China.

Pregelatinized starch This product is white powder, odorless, tasteless, and has good fluidity. The national product has an angle of repose of 36.6 degrees and has good compressibility; it has a lubricating effect and can reduce the force of the tablet ejecting from the die hole; it is good The disintegration effect and dry adhesiveness of the tablet can increase the hardness of the tablet and reduce the friability. This product is an ideal multifunctional auxiliary material for powder direct compression, and the dosage is generally 5%-20%.

Lactose spray-dried lactose is a white crystalline powder, non-hygroscopic; the surface of the compressed tablet is smooth and beautiful, and the drug is released quickly; it has good fluidity and adhesion, which is ideal for tablets. Of fillers. When the amount is greater than 50%, the hydrophobicity of the drug can be improved.

Sodium Carboxymethyl Starch This product is an excellent disintegrant for tablets. It is a white or off-white powder, odorless, has hygroscopicity in the air, and disperses into a viscous colloidal solution in water; it has good hydrophilicity and water absorption Expansibility; and has good fluidity and compressibility, can improve the formability of the tablet, increase the hardness of the tablet without affecting its disintegration. For tablets of poorly soluble drugs, this product can improve their disintegration. The general dosage is 1% to 8%.

   Calcium hydrogen phosphate This product is white powder, odorless, tasteless, insoluble in water or ethanol, and has moisture resistance; it has good fluidity and stability, and is inexpensive; the compressed tablets have good hardness. When the tablet contains 50% dibasic calcium phosphate, it disintegrates very quickly.

   Micro-powder silica gel This product is a light white anhydrous powder, odorless, tasteless, and has a large specific surface area. It is a commonly used tablet glidant and has greater adhesion to drugs. It has strong hydrophilic properties. When the dosage is more than 1%, it can accelerate the disintegration of the tablet, and the disintegration is extremely fine, which can improve the dissolution of the drug and facilitate the absorption of the drug. The general dosage is 0.15% to 3%.

   Magnesium Stearate This product is a white, easy and sand-free fine powder. It has a slippery feel in contact with the skin. It is insoluble in water and has good adhesion. This product is a commonly used hydrophobic lubricant, which can effectively solve the phenomenon of sticking and punching, and has a smooth and beautiful surface. The general dosage is 0.2% to 1%.

  Others such as low-substituted hydroxypropyl cellulose, starch, talc-magnesium stearate mixed powder, aluminum-magnesium raw powder, etc.

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