Search

申美

CN / EN

版权信息

Copyright:Shanghai Shenmei Pharmaceutical Technology Co., LTD | 沪ICP备09052914号-1

NEWS

一 新闻中心 一

>
>
>
Common types of direct compression accessories and characteristics

Common types of direct compression accessories and characteristics

Page view
Microcrystalline cellulose This product is white or off-white powder, odorless, tasteless, insoluble in water, ethanol, acetone or toluene, has very good compressibility, and has certain fluidity and disintegration. It is a tablet. Excellent filler and effective dry adhesive, it has good hardness after being pressed into tablets, and does not affect disintegration. The variety has a large capacity for the drug, and its dosage can be from 5% to 65%. However, this variety is hygroscopic. Now there are already products in China.
Pre-gelatinized starch This product is white powder, odorless, tasteless, good fluidity, national product angle of repose is 36.6 degrees, good compressibility; lubrication, can reduce the force of the tablet from the die hole; good The disintegration and dry adhesion increase the hardness of the tablet and reduce the friability. This product is an ideal multi-functional auxiliary material for direct compression of powder. The dosage is generally 5%~20%.
Lactose spray-dried lactose is an auxiliary material used for direct compression of powder. It is a white crystalline powder and has no hygroscopicity. The surface of the pressed tablet is smooth and beautiful, and the drug is released quickly. The fluidity and adhesion are good. Filler. When the amount is more than 50%, the hydrophobicity of the drug can be improved.
Sodium carboxymethyl starch This product is an excellent disintegrating agent for tablets. It is white or off-white powder, odorless, hygroscopic in air, dispersed into a viscous colloidal solution in water; has good hydrophilicity and water absorption. Swellability; and good fluidity and compressibility, can improve the formability of the tablet, increase the hardness of the tablet without affecting its disintegration. For tablets of poorly soluble drugs, this product can improve its disintegration. The general dosage is 1% to 8%.
Calcium hydrogen phosphate This product is a white powder, odorless, tasteless, insoluble in water or ethanol, has moisture resistance; has good fluidity and stability, and is inexpensive; the pressed tablet has good hardness. When the tablet contains 50% calcium hydrogen phosphate, the disintegration is very rapid.
Micro-silica gel This product is a light white anhydrous powder, odorless, odorless, large specific surface area, is a commonly used tablet glidant, has a greater adhesion to drugs. The hydrophilic property is strong, and when the dosage is above 1%, the disintegration of the tablet can be accelerated, and the disintegration is extremely fine, thereby improving the dissolution of the drug and facilitating the absorption of the drug. The general dosage is 0.15% to 3%.
Magnesium stearate This product is a white, easy and no-sand fine powder. It has a slippery feel when in contact with the skin. It is insoluble in water and has good adhesion. This product is a commonly used hydrophobic lubricant, which can effectively solve the sticking phenomenon, and the surface is smooth and beautiful. The general dosage is 0.2% to 1%.
Others such as low-substituted hydroxypropyl cellulose, starch, talc-magnesium stearate mixed powder, aluminum-magnesium raw powder and the like.